Peer-Reviewed Research and Clinical Evidence

LifeAire Systems

LifeAire Systems’ performance claims are supported by IRB-approved, double-blind operational clinical studies conducted in full-capacity real-world environments and published in peer-reviewed indexed journals. The research library below includes peer-reviewed publications, independent third-party studies, conference abstracts, and white papers across hospital, IVF, long-term care, and life sciences applications.

The Impact of Comprehensive and Live Air Purification on Health Resource Utilization (HRU)​

A conference abstract presented at the Academic Surgical Congress examining the impact of comprehensive and live air purification on health resource utilization in an acute care hospital setting. The abstract presents findings from the St. Luke's University Health Network research team — the same team whose full 12-month retrospective cohort study of 8,255 patients was subsequently published in the journal Surgery in September 2020. The data examines the relationship between advanced air purification and measurable improvements in patient length of stay, discharge outcomes, and healthcare economics. Presented at the Academic Surgical Congress, 2020. Authors: Wolfe, S.; Brisendine, C.; Levicoff, L.; Eid, S.; Zangari, M.; Ford, F.; Snyder, B.; Moyer, W.; Stawicki, S.P.

The Effects of Air Purification Technology on Clinical and Economic Outcomes

A conference presentation delivered at the Keystone Chapter of the American College of Surgeons Annual Meeting, 2019, examining the effects of LifeAire's advanced air purification technology on clinical and economic outcomes in an acute care hospital setting. The presentation represents early findings from the St. Luke's University Health Network research program that culminated in the full 12-month retrospective cohort study of 8,255 patients published in the journal Surgery in September 2020, documenting a 39.5% reduction in patient length of stay, trending reduction in HAIs, and 23% improvement in per-bed economics. Presented at the Keystone Chapter, American College of Surgeons Annual Meeting, 2019.

Modeling of airborne embryonic volatile compounds (VOCs) in the IVF culture environment – their concomitant cytotoxic concentration within the growth media and embryo.

A peer-reviewed conference abstract published in Fertility and Sterility, Volume 112, Issue 3, presenting early modeling research on the behavior of airborne volatile organic compounds in IVF culture environments. Using equilibrium partitioning models, the study demonstrates how airborne VOCs partition from the air phase through the oil cover layer into water-based culture media and into or onto the embryo itself, reaching cytotoxic concentrations even at low ambient air concentrations. Seven VOCs — including acrolein, formaldehyde, phenol, toluene, acetaldehyde, ethanol, and isopropanol — were identified as of particular concern to embryologists and clinicians. This conference abstract preceded the full peer-reviewed publication in Reproductive BioMedicine Online in 2022. Published in Fertility and Sterility, 2019; 112(3):E122-E123. Authors: Worrilow, K.C.; Urrutia, A.R.; Huynh, H.T.; Fox, J.T.

Comprehensive and live air purification as a key environmental, clinical, and patient safety factor: A prospective evaluation

A peer-reviewed book chapter published in Vignettes in Patient Safety, Volume 4, edited by Stanislaw P. Stawicki and Michael S. Firstenberg (IntechOpen, March 2019). The chapter presents the first comprehensive prospective evaluation of infectious and aerosolized pathogens — including their speciation, location, and concentration — within a typical hospital setting, and examines the relationship between airborne pathogens and air filtration methodologies in the context of the molecular and microbial epidemiology of illness and infection in clinical environments. The study represents foundational environmental evidence from St. Luke's University Health Network that preceded the full retrospective cohort study published in Surgery in 2020. Published in IntechOpen, March 2019. DOI: 10.5772/intechopen.84530. Authors: Stawicki, S.P.; Brisendine, C.; Levicoff, L.; Ford, F.; Snyder, B.; Eid, S.; Worrilow, K.C.

Multi-center study: Innovative Control of ambient air quality in multiple IVF laboratories is associated with statistically significant improvements in clinical outcomes – analysis of 5319 cycles.

An independent multi-center peer-reviewed study published in Fertility and Sterility, Volume 106, Issue 3 Supplement, 2016, examining the impact of innovative ambient air quality control on clinical outcomes across multiple IVF laboratories. The study analyzed 5,319 IVF cycles across multiple independent fertility programs and documented a statistically significant 14.9 percentage point increase in ongoing pregnancy rates across all age groups in laboratories using LifeAire's air quality control technology compared to controls. This independent, externally authored study — conducted entirely by IVF clinicians and scientists with no affiliation to LifeAire — represents the foundational clinical evidence supporting LifeAire's effectiveness in IVF settings and is the most-cited IVF outcome study in LifeAire's published research library. Published in Fertility and Sterility, 2016; 106(3 Suppl):e27-e28. Authors: Palter, S.; DiPaola, K.; Sparks, A.E.; Degelos, S.; Koulianos, G.T.; Young, J.; Halicigil, C.; Yalcinkaya, T.; She, E.; Bartolucci, A.

Statistically significant improvements in clinical outcomes using engineered molecular media and genomically modeled ultraviolet light for comprehensive control of Ambient Air (AA) quality.

A peer-reviewed conference abstract published in Fertility and Sterility, Volume 102, 2014, examining the impact of LifeAire's Aire~IVF air purification system on clinical outcomes in 1,245 non-donor IVF patients across three fertility programs over 24 months. The study evaluated the effect of comprehensive ambient air quality control — using engineered molecular media and genomically modeled ultraviolet light — on key IVF outcome metrics. Results demonstrated statistically significant improvements in implantation rate, clinical pregnancy rate, ongoing pregnancy rate, and blastocyst conversion rate following system installation, with blastocyst conversion rate increasing from 57.1% to 67.6%. The findings confirm that controlling airborne pathogens and improving ambient air quality are critical factors in optimizing embryogenesis outcomes. Published in Fertility and Sterility, 2014; 102:e91. DOI: 10.1016/j.fertnstert.2014.07.307. Authors: Forman, M.; Sparks, A.E.T.; Degelos, S.; Koulianos, G.; Worrilow, K.C.
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