2025 | Russack, J. S., J. T. Fox, H. T. Huynh, K. C. Worrilow, and D. G. Brown.
Applied In Vitro Toxicology 11, no. 4
Abstract
Introduction
Volatile organic compounds (VOCs) are ubiquitous in indoor air spaces, including the most sensitive medical environments. In assisted reproductive technology facilities, VOCs are known to greatly decrease embryo implantation rates and may impact embryo growth rate as well as miscarriage rates. There is reason to believe that the observed impacts of VOCs translate into parallel industries as well, such as the emerging cell and gene therapy industry. Previous modeling efforts on VOC transport into cell culture media components have provided estimates on the expected equilibrium concentrations from airborne VOC exposure. However, a fundamental knowledge gap remains regarding the rate of VOC partitioning into cell cultures.