Low-Level Volatile Organic Compounds Disrupt Embryo Morphokinetics and Development in Murine Preimplantation Embryos
A peer-reviewed poster abstract published in Fertility and Sterility, October 2024, examining the impact of low-level volatile organic compounds on embryo morphokinetics and development in murine preimplantation embryos. Current IVF guidelines recommend maintaining VOC levels between 400 and 800 ppb, yet this study presents emerging evidence that VOCs below that threshold can adversely affect specific metrics of embryogenesis. Using time-lapse analysis, the study assessed the impact of low-level VOC exposure on developmental timing across multiple embryo stages. The findings strengthen the scientific rationale for maintaining VOC concentrations well below current clinical thresholds in IVF laboratory environments. Published in Fertility and Sterility, October 2024. Authors: Orsolini, M.; Schenkman, E.; Russack, J.S.; Huynh, H.T.; Schust, D.J.; Worrilow, K.C.; Fox, J.T.