Predicting Airborne Volatile Organic Compound Transport in Highly Sensitive In Vitro Processes and Biopharmaceutical Manufacturing Facilities with Kinetic Models
A peer-reviewed study published in Applied In Vitro Toxicology, Volume 11, Issue 4, 2025, presenting kinetic models for predicting the transport of airborne volatile organic compounds into cell culture systems in highly sensitive in vitro processes and biopharmaceutical manufacturing facilities. Building on prior equilibrium partitioning modeling work, this study addresses a fundamental knowledge gap regarding the rate of VOC partitioning into cell cultures — critical for understanding how airborne contamination affects both IVF embryo culture outcomes and cell and gene therapy manufacturing processes. The models demonstrate how VOC transport rates from ambient air into culture media can be predicted and managed, with direct implications for air quality standards in IVF laboratories and biopharmaceutical cleanrooms. Published in Applied In Vitro Toxicology, Volume 11, Issue 4, 2025. Authors: Russack, J.S.; Fox, J.T.; Huynh, H.T.; Worrilow, K.C.; Brown, D.G.